Kev Dhaliwal
Personal Chair of Molecular Imaging & Healthcare Technology
Email: Kev.Dhaliwal@ed.ac.uk
Kev is a Professor of Molecular Imaging and Healthcare Technology at the University of Edinburgh and a Consultant Physician in Respiratory Medicine. He has a passion for developing new technologies for healthcare impact and is the Chief Investigator on six first-in-human trials of optical molecular imaging reagents and devices related to the diagnosis of bacterial infection, inflammation and cancer. Collaborating widely with industry, he is an advocate of the need to work across scientific disciplines and translate physical science research into healthcare.
Publications
Selective plane illumination optical endomicroscopy with polymer imaging fibers (2023)
Roldán-Varona P, Ross CA, Rodríguez-Cobo L, López-Higuera JM, Gaughan E, Dhaliwal K, Tanner MG, Thomson RR, Parker HE.
FluoroPi Device With SmartProbes: A Frugal Point-of-Care System for Fluorescent Detection of Bacteria From a Pre-Clinical Model of Microbial Keratitis (2023)
Mohanan SMPC, Russell K, Duncan S, Kiang A, Lochenie C, Duffy E, Kennedy S, Prajna NV, Williams RL, Dhaliwal K, Williams GOS, Mills B.
Computational Fluorescence Suppression in Shifted Excitation Raman Spectroscopy (2023).
Jenkins N, Ehrlich K, Kufcsak A, Yerolatsitis S, Fernandes S, Young I, Hamilton K, Wood HA, Quinn T, Young V, Akram AR, Stone JM, Thomson RR, Finlayson K, Dhaliwal K, Seth S.
Environmentally sensitive photosensitizers enable targeted photodynamic ablation of Gram-positive antibiotic resistant bacteria (2023)
Benson S, Kiang A, Lochenie C, Lal N, Mohanan SMPC, Williams GOS, Dhaliwal K, Mills B, Vendrell M.
Specific in situ immuno-imaging of pulmonary-resident memory lymphocytes in human lungs (2023)
Humphries DC, O’Connor RA, Stewart HL, Quinn TM, Gaughan EE, Mills B, Williams GOS, Stone JM, Finlayson K, Chabaud-Riou M, Boudet F, Dhaliwal K, Pavot V.
Simultaneous Spectral Temporal Modelling for a Time-Resolved Fluorescence Emission Spectrum (2023)
Adams AC, Kufcsak A, Ehrlich K, Dhaliwal K, Seth S.
Tri-mode optical biopsy probe with fluorescence endomicroscopy, Raman spectroscopy, and time-resolved fluorescence spectroscopy (2022).
Wood HA, Ehrlich K, Yerolatsitis S, Kufcsák A, Quinn TM, Fernandes S, Norberg D, Jenkins NC, Young V, Young I, Hamilton K, Seth S, Akram AR,Thomson RR, Finlayson K, Dhaliwal K, Stone JM.
High resolution TCSPC imaging of diffuse light with a one-dimensional SPAD array scanning system (2022).
E P McShane, H K Chandrasekharan, A Kufcsák, N Finlayson, A T Erdogan, R K Henderson, K Dhaliwal, R R Thomson, M G Tanner
An Inhaled Galectin-3 Inhibitor in COVID-19 Pneumonitis (DEFINE): A Phase Ib/IIa Randomised Controlled Trial (2022).
Gaughan EE, Quinn TM, Mills A, Bruce A M, Antonelli J, Mackinnon A, Aslanis V, Li F, O’connor R, Boz C, Mills R, Emanuel P, Burgess M, Rinaldi G, Valanciute A, Mills B, Scholefield E, Hardisty G, Gwyer Findlay E, Parker R A, Norrie J, Dear JW, Akram AR, Koch O, Templeton K, Dockrell DH, Walsh TS, Partridge S, Humphries D, Wang-Jairaj J, Slack RJ, Schambye H, Phung D, Gravelle L, Lindmark B, Shankar-Hari M, Hirani N, Sethi T, Dhaliwal K.
Randomised Controlled Trial of Intravenous Nafamostat Mesylate in COVID pneumonitis: Phase 1b/2a Experimental Study to Investigate Safety, Pharmacokinetics and Pharmacodynamics (2022).
Quinn T, Gaughan E E, Bruce A, Antonelli J, O’Connor R A, Li F, McNamara S, Koch O, Mackintosh C, Dockrell D, Walsh T, Blyth K G, Church C, Schwarze J, Boz C, Valanciute A, Burgess M, Emanuel P, Mills B, Rinaldi G, Hardisty G, Mills R, Findlay EG, Jabbal S, Duncan A, Plant S, Marshal ADL, Young I, Russell K, Scholefield E, Nimmo AF, Nazarov IB, Churchill GC, McCullagh JSO, Ebrahimi KH, Ferrett C, Templeton K, Rannard S, Owen A, Moore A, Finlayson K, Shankar-Hari M, Norrie J, Parker RA, Akram AR, Anthony DC, Dear JW, Hirani N, Dhaliwal K.
Fibroblast Activation Protein specific optical imaging in Non-Small Cell Lung Cancer (2022).
Mathieson L, O’Connor R A, Stewart H, Shaw P, Dhaliwal K, Williams G, Megia-Fernandez A, Akram A R.
Diagnosing ventilator-associated pneumonia (VAP) in UK NHS ICUs: the perceived value and role of a novel optical technology (2022).
Jones W S, Suklan J, Winter A, Green, K, Craven T, Bruce A, Mair J, Dhaliwal K, Walsh T, Simpson A J, Graziadio S, Allen A J.
Fast and robust single-exponential decay recovery from noisy fluorescence lifetime imaging (2022).
Taimori A, Humphries D, Williams G, Dhaliwal K, Finlayson N, Hopgood J R.
Phototherapeutic Induction of Immunogenic Cell Death and CD8+ T Cell-Granzyme B Mediated Cytolysis in Human Lung Cancer Cells and Organoids (2022).
Valančiūtė A, Mathieson L, O’Connor R A, Scott J I, Vendrell M, Dorward D A, Akram A R, Dhaliwal K.
Deep Learning-Assisted Co-registration of Full-Spectral Autofluorescence Lifetime Microscopic Images with H&E-Stained Histology Images (2022).
Wang Q, Fernandes S, Williams G, Finlayson N, Akram A R, Dhaliwal K, Hopgood J R, Vallejo M.
Design and Modelling of a Continuum Robot for Distal Lung Sampling in Mechanically Ventilated Patients in Critical Care (2021).
Mitros Z, Thamo B, Bergeles C, Da Cruz L, Dhaliwal K, Khadem M.
Humphries DC, O’Connor RA, Larocque D, Chabaud-Riou M, Dhaliwal K, Pavot V.
Full spectrum fluorescence lifetime imaging with 0.5 nm spectral and 50 ps temporal resolution (2021)
Williams GOS, Williams E, Finlayson N, Erdogan AT, Wang Q, Fernandes S, Akram AR, Dhaliwal K, Henderson RK, Girkin JM, Bradley M.
Fernandes S, Williams G, Williams E, Ehrlich K, Stone J, Finlayson N, Bradley M, Thomson RR, Akram AR, Dhaliwal K.
Tissue proteomic analysis identifies mechanisms and stages of immunopathology in fatal COVID-19 (2021)
Russell C D, Valanciute A, Gachanja N, Stephen J, Penrice-Randal R, Armstrong S D, Clohisey S, Wang B, Al Qsous W, Wallace W, Oniscu G, Stevens J, Harrison D J, Dhaliwal K, Hiscox J A, Baillie J K, Akram A R, David D, Lucas C D.
T cells drive negative feedback mechanisms in Cancer Associated Fibroblasts, promoting expression of co-inhibitory ligands, CD73 and IL-27 in non-small cell lung cancer (2021)
O’Connor R A, Chauhan V, Mathieson L, Titmarsh H, Koppensteiner L, Young I, Tagliavini G, Dorward D, Prost S, Dhaliwal K, Wallace W, Akram A R.
Activated neutrophil fluorescent imaging technique for human lungs (2021).
Craven T H, Walton T, Akram A R, Scholefield E, Mcdonald N, Marshall A D L, Humphries D C, Mills B, Campbell T A, Bruce A, Mair J, Dear J W, Newby D E, Hill A T, Walsh T S, Haslett C, Dhaliwal K.
Deep Learning in ex-vivo Lung Cancer Discrimination using Fluorescence Lifetime Endomicroscopic Images (2020).
Wang Q, Hopgood JR, Finlayson N, Williams GO, Fernandes S, Williams E, Akram A, Dhaliwal K, Vallejo M.
Frugal filtering optical lenses for point-of-care diagnostics (2020)
Long J, Parker HE, Ehrlich K, Tanner MG, Dhaliwal K, Mills B.
Time-Resolved Spectroscopy of Fluorescence Quenching in Optical Fibre-Based pH Sensors (2020)
Ehrlich K, Choudhary TR, Ucuncu M, Megia-Fernandez A, Harrington K, Wood HAC, Yu F, Choudhury D, Dhaliwal K, Bradley M, Tanner MG.
Polymyxin-based photosensitizer for the potent and selective killing of Gram-negative bacteria (2020).
Ucuncu M, Mills B, Duncan S, Staderini M, Dhaliwal K, Bradley M.
Exploratory use of fluorescent SmartProbes for the rapid detection of microbial isolates causing corneal ulcer (2020).
Mills B, Megia-Fernandez A, Bradley M, Dhaliwal K, Williams R, Gunasekaran R, Lalitha P, Prajna NV.
Molecular detection of Gram-positive bacteria in the human lung through an optical fiber–based endoscope (2020).
Mills B, Megia-Fernandez A, Norberg D, Duncan S, Marshall A, Akram AR, Quinn T, Young I, Bruce AM, Scholefield E, Williams GOS, Krstajić N, Choudhary TR, Parker HE, Tanner MG, Harrington K, Wood HAC, Birks TA, Knight JC, Haslett C, Birks TA, Knight JC, Haslett C, Dhaliwal K, Bradley M, Ucuncu M, Stone JM.
A matrix metalloproteinase activation probe for painting human tumours (2020).
Mills B, Norberg D, Dhaliwal K, Akram AR, Bradley M, Megia-Fernandez A.
Parker HE, Stone JM, Marshall ADL, Choudhary TR, Thomson RR, Dhaliwal K, Tanner MG
In situ identification of Gram-negative bacteria in human lungs using a topical fluorescent peptide targeting lipid A (2018).
Akram AR, Chankeshwara SV, Scholefield E, Aslam T, McDonald N, Megia-Fernandez A, Marshall A, Mills B, Avlonitis N, Craven TH, Smyth AM, Collie DS, Gray C, Hirani N, Hill AT, Govan JR, Walsh T, Haslett C, Bradley M, Dhaliwal K.
Early arriving photon imaging for locating optical endomicroscopy fibres and medical devices (2018).
Tanner M G, Choudhary T, Craven T, Mills B, Bradley M, Henderson R, Dhaliwal K, Thomson RR.
Bimodal fluorogenic sensing of matrix proteolytic signatures in lung cancer (2018).
Megia-fernandez A, Mills B, Michels C, Chankeshwara, S V, Krstajić N, Haslett C, Dhaliwal K, Bradley M.
Low-cost high sensitivity pulsed endomicroscopy to visualize tricolor optical signatures (2018)
Krstajić N, Mills B, Murray I, Marshall A, Norberg D, Craven TH, Emanuel P, Choudhary TR, Williams GOS, Scholefield E, Akram AR, Davie A, Hirani N, Bruce A, Moore A, Bradley M, Dhaliwal K.
Development of an Alveolar Transbronchial Catheter for Concurrent Fiber Optics-Based Imaging and Fluid Delivery (2018).
Knighton N, Cottle B, Dentan V, Vercauteren T, Akram A, Bruce A, Dhaliwal K, Hitchcock R.
Super-silent FRET sensor enables live cell imaging and flow cytometric stratification of intracellular serine protease activity in neutrophils (2018).
Craven TH, Avlonitis N, McDonald N, Walton T, Scholefield E, Akram AR, Walsh TS, Haslett C, Bradley M, Dhaliwal K.
High fidelity fibre-based physiological sensing deep in tissue (2018)
Choudhary TR, Tanner MG, Megia-Fernandez A, Harrington K, Wood HA, Marshall A, Zhu P, Chankeshwara SV, Choudhury D, Monro G, Ucuncu M, Yu F, Duncan RR, Thomson RR, Dhaliwal K, Bradley M.
Cerebral Concussion Primes the Lungs for Subsequent Neutrophil-Mediated Injury (2018)
Humphries DC, O’Neill S, Scholefield E, Dorward DA, Mackinnon AC, Rossi AG, Haslett C, Andrews PJD, Rhodes J, Dhaliwal K
Dorward DA, Lucas CD, Doherty MK, Chapman GB, Scholefield E, Morris AC, Felton JM, Kipari T, Humphries D, Robb CT, Simpson AJ, Whitfield PD, Haslett C, Dhaliwal K, Rossi AG.
pH sensing through a single optical fibre using SERS and CMOS SPAD line arrays (2017)
K Ehrlich, A Kufcsák, S McAughtrie, H Fleming, N Krstajic, C J Campbell, R K Henderson, K Dhaliwal, R R Thomson, M G Tanner.
Highly selective and rapidly activatable fluorogenic Thrombin sensors and application in human lung tissue (2017)
Megia-fernandez A, Mills B, Michels C, Chankeshwara SV, Dhaliwal K, Bradley M.
Ballistic and snake photon imaging for locating optical endomicroscopy fibres (2017).
Tanner MG, Choudhary TR, Craven TH, Mills B, Bradley M, Henderson RK, Dhaliwal K, Thomson, RR.
Optical Screening of Novel Bacteria-specific Probes on Ex Vivo Human Lung Tissue by Confocal Laser Endomicroscopy (2017).
Mills B, Akram AUH, Scholefield E, Bradley M, Dhaliwal K.
Time-resolved spectroscopy at 19,000 lines per second using a CMOS SPAD line array enables advanced biophotonics applications (2017).
A Kufcsák, A Erdogan, R Walker, K Ehrlich, M Tanner, A Megia-Fernandez, E Scholefield, P Emanuel, K Dhaliwal, M Bradley, R K Henderson, N Krstajić.
Assessing the utility of autofluorescence-based pulmonary optical endomicroscopy to predict the malignant potential of solitary pulmonary nodules in humans (2016).
Seth S, Akram AR, McCool P, Westerfeld J, Wilson D, McLaughlin S, Dhaliwal K, Williams CK.
Endoscopic sensing of alveolar pH (2016).
Choudhury D, Tanner MG, McAughtrie S, Yu F, Mills B, Choudhary TR, Seth S, Craven TH, Stone JM, Mati IK, Campbell CJ , Bradley M, Williams CKI, Dhaliwal K, Birks TA, Thomson RR.
A labelled-ubiquicidin antimicrobial peptide for immediate in situ optical detection of live bacteria in human alveolar lung tissue (2015).
Akram AR, Avlonitis N, Lilienkampf A, Perez-Lopez AM, McDonald N, Chankeshwara SV, Scholefield E, Haslett C, Bradley M, Dhaliwal K.