Models for Pre-clinical Testing

We have developed several translationally relevant model systems optimised for clinical tractability.

These include:

• Freshly-excised human lung tissues (from non-small cell lung cancer and IPF),

   

• Human lungs (obtained a UK wide consortium and deemed not fit for transplant) which can be ventilated and perfused on an ex-vivo lung perfusion system (EVLP)

   

• Tissue derived from cull-stock animals (therefore in keeping with the principles of the 3 R’s in animal research).

  These models range from single cell, organoid, precision-cut lung slices to whole human lungs. This work also enables discovery work for tractable targets and for imaging in humans